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Differential effects of nanoselenium doping on healthy and cancerous osteoblasts in coculture on titanium

Authors Tran PA, Sarin L, Hurt RH, Webster T 

Published 10 May 2010 Volume 2010:5 Pages 351—358


Review by Single anonymous peer review

Peer reviewer comments 2

Phong A Tran1, Love Sarin2, Robert H Hurt2, Thomas J Webster2,3

1Physics Department,2Division of Engineering,3Department of Orthopedic Surgery, Brown University, Providence, RI, USA

Abstract: In the present study, selenium (Se) nanoclusters were grown through heterogeneous nucleation on titanium (Ti) surfaces, a common orthopedic implant material. Normal healthy osteoblasts (bone-forming cells) and cancerous osteoblasts (osteosarcoma) were cultured on the Se-doped surfaces having three different coating densities. For the first time, it is shown that substrates with Se nanoclusters promote normal osteoblast proliferation and inhibit cancerous osteoblast growth in both separate (mono-culture) and coculture experiment. This study suggests that Se surface nanoclusters can be properly engineered to inhibit bone cancer growth while simultaneously promoting the growth of normal bone tissue.

Keywords: selenium, coating, nanotechnology, biomaterials, orthopedics, bone cancer

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