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Differential effects of dopamine-directed treatments on cognition

Authors Ashby FG, Valentin V, von Meer S

Received 1 May 2015

Accepted for publication 9 June 2015

Published 29 July 2015 Volume 2015:11 Pages 1859—1875

DOI https://doi.org/10.2147/NDT.S65875

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Miao Sun

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Video abstract presented by Gregory Ashby

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F Gregory Ashby, Vivian V Valentin, Stella S von Meer

Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA, USA

Abstract: Dopamine, a prominent neuromodulator, is implicated in many neuropsychiatric disorders. It has wide-ranging effects on both cortical and subcortical brain regions and on many types of cognitive tasks that rely on a variety of different learning and memory systems. As neuroscience and behavioral evidence for the existence of multiple memory systems and their corresponding neural networks accumulated, so did the notion that dopamine’s role is markedly different depending on which memory system is engaged. As a result, dopamine-directed treatments will have different effects on different types of cognitive behaviors. To predict what these effects will be, it is critical to understand: which memory system is mediating the behavior; the neural basis of the mediating memory system; the nature of the dopamine projections into that system; and the time course of dopamine after its release into the relevant brain regions. Consideration of these questions leads to different predictions for how changes in brain dopamine levels will affect automatic behaviors and behaviors mediated by declarative, procedural, and perceptual representation memory systems.

Keywords: dopamine, cognition, memory systems, learning

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