Back to Journals » Cancer Management and Research » Volume 12

Diagnostic Value of Combining miRNAs, CEA Measurement and the FOBT in Colorectal Cancer Screening

Authors Li X, Chen R, Li Z, Luo B, Geng W, Wu X

Received 17 November 2019

Accepted for publication 14 February 2020

Published 15 April 2020 Volume 2020:12 Pages 2549—2557

DOI https://doi.org/10.2147/CMAR.S238492

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Rudolph Navari


Xiaodan Li,1 Rong Chen,2 Zhifa Li,2 Bing Luo,1 Wenyan Geng,1 Xiaobing Wu2

1Clinical Laboratory, The Third Affiliated Hospital of the Guangzhou Medical University, Guangzhou 510150, People’s Republic of China; 2Gastrointestinal Surgery, The Third Affiliated Hospital of the Guangzhou Medical University, Guangzhou 510150, People’s Republic of China

Correspondence: Xiaobing Wu
Gastrointestinal Surgery, The Third Affiliated Hospital of the Guangzhou Medical University, NO. 63, Duobao Road, Liwan District, Guangzhou City, Guangdong Prov 510150, People’s Republic of China
Tel +8613544395215
Fax +02081292182
Email wuxiaobing270@126.com

Introduction: Colorectal cancer (CRC) is one of the most common illnesses that seriously threatens human health; many papers have reported that microRNAs (miRNAs) are promising biomarkers for cancer detection. However, miRNAs have not been used in clinical practice even though they are superior to the currently used screening tools, such as the fecal occult blood test (FOBT) and carcinoembryonic antigen (CEA) measurement.
Methods: In this study, we focused on the usefulness of a panel of miRNAs and the combination of miRNAs with the FOBT and CEA measurement, the currently used general diagnosis methods, to improve the accuracy of CRC diagnosis.
Results: The results showed that the miRNA panel has great potential value as a diagnostic biomarker with high specificity and sensitivity, and further analysis demonstrated that the miRNA panel had higher sensitivity and specificity than the FOBT and CEA measurement, even when these methods were combined. More importantly, although the miRNA panel is superior to the FOBT and CEA measurement, it cannot replace them.
Conclusions: In this research, we investigated whether complementarity exists between the miRNA panel and the FOBT and CEA measurement for CRC diagnosis. Interestingly, the results indicated that the FOBT and CEA measurement could improve the positivity rate of the miRNA panel as a biomarker and vice versa.

Keywords: microRNAs, colorectal cancer, biomarker

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]