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Diagnostic challenges in primary orbital fibrosarcoma: a case report

Authors Scruggs B, Ho S, Valenzuela A

Received 9 July 2014

Accepted for publication 14 August 2014

Published 20 November 2014 Volume 2014:8 Pages 2319—2323


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Brittni A Scruggs, Son T Ho, Alejandra A Valenzuela

Department of Ophthalmology, School of Medicine, Tulane University, New Orleans, LA, USA

Abstract: Fibrosarcoma is a rare and malignant spindle cell tumor of mesenchymal origin that infrequently presents in the orbit. Evolving diagnostic criteria confound the identification of these tumors, as well as the interpretation of previous studies on this unusual entity. We report a case of a 66-year-old man with a mass on his left inferior orbit, with associated paresthesia. A computed tomography (CT) scan showed a lesion on the left anteroinferomedial orbit, with bone erosion. An en bloc surgical excision followed by a thorough immunohistologic evaluation allowed diagnosis of an orbital fibrosarcoma. The patient has had no recurrence after 14 months of follow up. Once a commonly identified soft tissue malignancy, fibrosarcoma has become a diagnosis of exclusion as a result of improved diagnostic and classification techniques, such as immunohistochemistry and fluorescence in situ hybridization (FISH). This type of soft tissue tumor is now an uncommon entity, and we report the first case of a primary orbital fibrosarcoma in an adult, using modern diagnostic and classification methods.

Keywords: spindle cell orbital tumor, mesenchymal tumor, soft tissue malignancy, fibroblasts

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