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Diagnostic and therapeutic utility of neuroimaging in depression: an overview

Authors Wise T, Cleare A, Herane A, Young A, Arnone D

Received 16 April 2014

Accepted for publication 22 May 2014

Published 19 August 2014 Volume 2014:10 Pages 1509—1522


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Toby Wise,1 Anthony J Cleare,1 Andrés Herane,1,2 Allan H Young,1 Danilo Arnone1

1King’s College London, Institute of Psychiatry, Department of Psychological Medicine, Centre for Affective Disorders, London, United Kingdom; 2Clínica Psiquiátrica Universitaria, Universidad de Chile, Santiago, Chile

Abstract: A growing number of studies have used neuroimaging to further our understanding of how brain structure and function are altered in major depression. More recently, these techniques have begun to show promise for the diagnosis and treatment of depression, both as aids to conventional methods and as methods in their own right. In this review, we describe recent neuroimaging findings in the field that might aid diagnosis and improve treatment accuracy. Overall, major depression is associated with numerous structural and functional differences in neural systems involved in emotion processing and mood regulation. Furthermore, several studies have shown that the structure and function of these systems is changed by pharmacological and psychological treatments of the condition and that these changes in candidate brain regions might predict clinical response. More recently, “machine learning” methods have used neuroimaging data to categorize individual patients according to their diagnostic status and predict treatment response. Despite being mostly limited to group-level comparisons at present, with the introduction of new methods and more naturalistic studies, neuroimaging has the potential to become part of the clinical armamentarium and may improve diagnostic accuracy and inform treatment choice at the patient level.

Keywords: depression, mood disorder, neuroimaging, diagnosis, treatment

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