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Diagnosis and screening of patients with generalized pustular psoriasis

Authors Ly K, Beck KM, Smith MP, Thibodeaux Q, Bhutani T

Received 31 March 2019

Accepted for publication 1 June 2019

Published 20 June 2019 Volume 2019:9 Pages 37—42

DOI https://doi.org/10.2147/PTT.S181808

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 3

Editor who approved publication: Professor Uwe Wollina


Karen Ly,* Kristen M Beck*, Mary P Smith, Quinn Thibodeaux, Tina Bhutani

Department of Dermatology, University of California, San Francisco, CA, USA

*These authors contributed equally to this work

Abstract: Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening variant of psoriasis that is characterized by recurrent, acute onset, widely distributed pustular eruptions on inflamed, erythematous skin. It is important to recognize acute GPP as a subtype of psoriasis associated with high morbidity and mortality so therapy can be initiated without delay. Since GPP was first described in 1910 by Leopold von Zumbusch, it has been inconsistently defined, stratified, and diagnosed in the literature. Multiple definitions and diagnostic criteria have been proposed over the years. Recently, formal consensus guidelines on GPP have been published by international groups. This article reviews the current evidence and understanding in the diagnosis and screening of GPP.

Keywords: generalized pustular psoriasis, acute generalized pustular psoriasis of von Zumbusch, pustular psoriasis, diagnostic criteria


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