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Diabetes Mellitus and Its Associated Factors in Tuberculosis Patients in Maekel Region, Eritrea: Analytical Cross-Sectional Study

Authors Araia ZZ, Mesfin AB, Mebrahtu AH, Tewelde AG, Osman R, Tuumzghi HA

Received 23 November 2020

Accepted for publication 21 January 2021

Published 4 February 2021 Volume 2021:14 Pages 515—523

DOI https://doi.org/10.2147/DMSO.S293557

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Juei-Tang Cheng


Zenawi Zeramariam Araia,1 Araia Berhane Mesfin,2 Amanuel Hadgu Mebrahtu,1 Adiam Ghebreyohanns Tewelde,3 Randa Osman,4 Hagos Andom Tuumzghi5

1National TB and Leprosy Control Program, Communicable Disease Control Division, Ministry of Health, Asmara, Eritrea; 2Communicable Diseases Control Division, Ministry of Health, Asmara, Eritrea; 3Integrated Disease Surveillance and Response, Ministry of Health, Asmara, Eritrea; 4Orrota College of Medicine and Health Sciences, Asmara, Eritrea; 5Ministry of Health, Maekel Region Branch, Asmara, Eritrea

Correspondence: Zenawi Zeramariam Araia
National TB and Leprosy Control Program, Communicable Diseases Control Division, Ministry of Health, Asmara, Eritrea
Tel +291-1-122129
Email zenhopncl@gmail.com

Background: Both diabetes mellitus (DM) and tuberculosis (TB) are among the leading causes of morbidity and mortality in Eritrea. TB-DM comorbidity is known to complicate TB care, control and prevention. However, systematically studied epidemiological data on TB-DM comorbidity and its associated risk factors are lacking in this country.
Objective: This study aimed to assess the prevalence of DM and its associated factors among TB patients in the Maekel region, Eritrea.
Methods: Analytical cross-sectional study was conducted in eleven TB diagnostic and treatment sites. Pretested data extraction tool was used to collect data from medical records. Prevalence data were analysed using frequencies, proportions and median. To determine DM risk factors, univariable and multivariable logistic regression analysis was done with 95% CI and p value < 0.05 considered significant.
Results: Out of total eligible (1134) TB cases, DM prevalence was 9.88%. Age and BMI were identified as independent risk factors for DM among TB patients. Higher odds of DM were found among TB patients aged 45– 54 (aOR: 4.85[1.39– 16.94], p= 0.013) and those ≥ 55 (aOR: 6.99[2.12– 23.04], p= 0.001). TB cases with normal BMI were two times more likely to have DM (aOR: 2.00[1.23– 3.26], p= 0.005) compared to those underweight.
Conclusion: The prevalence of DM among TB cases observed in this study is high, a clarion call to scale up current efforts to integrate TB-DM services within routine care. Furthermore, age and BMI were identified as independent risk factors for DM in TB cases, pointing to the need to pay attention to age and BMI status when managing this co-morbidity.

Keywords: TB-DM prevalence, transient hyperglycaemia, fasting blood glucose, pre-diabetes, Eritrea

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