Dexmethylphenidate hydrochloride in the treatment of attention deficit hyperactivity disorder
Authors Feng Liu, Haruka Minami, Raul R Silva
Published 15 December 2006 Volume 2006:2(4) Pages 467—473
Feng Liu, Haruka Minami, Raul R Silva
New York University School of Medicine, Division of Child and Adolescent Psychiatry, New York, NY, USA
Abstract: Attention-deficit/hyperactivity disorder (ADHD) affects a large number of children. For decades, the stimulants have been the mainstay of pharmacological treatment for ADHD. Dexmethylphenidate (d-MPH), the d-isomer of the traditional racemic mixtures of d,l-threo-(R,R)-MPH, was recently introduced as another potential option in the stimulant class of medications. This paper reviews and summarizes the available research literature on d-MPH regarding pharmacodynamic, pharmacokinetic, chemical structure, receptor binding, toxicology, and clinical perspectives. d-MPH potentially may offer some advantages in the realms of absorption and duration of action compared with its racemic counterpart. The differences in pharmacokinetics and clinical implications of the immediate-release and extended-release forms of d-MPH are also compared and contrasted.
Keywords: ADHD, dexmethylphenidate, chemistry, receptor binding, toxicology, pharmacokinetics