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Dexmedetomidine in perioperative acute pain management: a non-opioid adjuvant analgesic

Authors Tang C, Xia Z

Received 11 April 2017

Accepted for publication 19 July 2017

Published 11 August 2017 Volume 2017:10 Pages 1899—1904


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Katherine Hanlon

Chaoliang Tang, Zhongyuan Xia

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China

Abstract: Many nociceptive, inflammatory, and neuropathic pathways contribute to perioperative pain. Although opioids have long been a mainstay for perioperative analgesia, other non-opioid therapies, and dexmedetomidine, in particular, have been increasingly used as part of a multimodal analgesic regimen to provide improved pain control while minimizing opioid-related side effects. This article reviews the evidence supporting the preoperative, intraoperative, and postoperative efficacy of dexmedetomidine as an adjuvant, and the efficacy of intravenous, spinal canal, and nerve block analgesia with dexmedetomidine for perioperative acute pain treatment. While there have not been any large-scale clinical trials conducted, the current body of evidence suggests that dexmedetomidine is suitable for use as an adjuvant analgesic at all perioperative stages. However, there are potential adverse effects, such as hypotension and bradycardia, which must be taken into consideration by clinicians.

Keywords: dexmedetomidine, analgesia, perioperative pain, non-opioid, adjuvant

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