Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 5

Development of the Lung Function Questionnaire (LFQ) to identify airflow obstruction

Authors Barbara P Yawn, Douglas W Mapel, David M Mannino, et al

Published 17 December 2009 Volume 2010:5 Pages 1—10

DOI https://doi.org/10.2147/COPD.S7683

Review by Single-blind

Peer reviewer comments 3

Barbara P Yawn1, Douglas W Mapel2, David M Mannino3, Fernando J Martinez4, James F Donohue5, Nicola A Hanania6, Mark Kosinski7, Regina Rendas-Baum7, Matthew Mintz8, Steven Samuels9, Anand A Dalal10, On behalf of the Lung Function Questionnaire Working Group*

1Olmsted Medical Center, Department of Research, Rochester, MN, USA; 2Lovelace Clinic Foundation, Albuquerque, NM, USA; 3University of Kentucky School of Medicine, Lexington, KT, USA; 4University of Michigan Health System, Ann Arbor, MI, USA; 5University of North Carolina School of Medicine, Chapel Hill, NC, USA; 6Baylor College of Medicine, Houston, TX, USA; 7QualityMetric, Inc., Lincoln, RI, USA; 8George Washington University School of Medicine, Washington, DC, USA; 9Indiana Internal Medicine Consultants, Greenwood, IN, USA; 10GlaxosmithKline, Research Triangle Park, NC, USA; *The Lung Function Questionnaire Working Group includes Barbara P Yawn, Douglas W Mapel, David M Mannino, Fernando Martinez, James Donohue, Nicola Hanania, Matthew Mintz, and Steven Samuels

Objective: To describe the item-selection and item-reduction for the Lung Function Questionnaire (LFQ), being developed to help clinicians identify patients appropriate for diagnostic evaluation for chronic obstructive pulmonary disease (COPD) using spirometry.

Methods: Item selection and reduction were based on information from 387 ≥40-year-old respondents to the third National Health and Nutrition Examination Survey who had self-reported chronic bronchitis. Item reduction involved stepwise logistic regression. The accuracy of the final subset of items for identifying individuals with airflow obstruction (forced expiratory volume in one second/forced vital capacity <0.70) versus those without it was assessed with receiver operating characteristic analysis. Content and face validity were assessed using focus groups of primary care physicians (n = 16) and interviews with COPD patients (n = 16).

Results: The model with all five items (age; smoking history; the presence of wheeze, dyspnea, and phlegm) compared with models with combinations of fewer items had the highest classification accuracy (area under the curve [AUC] = 0.720) with sensitivity and specificity of 73.2% and 58.2%, respectively. The presence of three or more factors yielded the highest AUC, a result suggesting that three or more affirmative answers is the most appropriate criterion indicating presence of airflow obstruction.

Conclusions: The five-item LFQ retained sufficient accuracy, sensitivity, and specificity in identifying individuals with COPD for further validation testing.

Keywords: spirometry, chronic obstructive pulmonary disease, respiratory disease, chronic bronchitis, diagnosis, screening

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep

Lim K, Kim SY, Lee B, Segarra C, Kang S, Ju YR, Schmerr MJ, Coste J, Kim SY, Yokoyama T, An SSA

International Journal of Nanomedicine 2015, 10:241-250

Published Date: 9 September 2015

Ultrafast sonochemical synthesis of protein-inorganic nanoflowers

Batule BS, Park KS, Kim MI, Park HG

International Journal of Nanomedicine 2015, 10:137-142

Published Date: 25 August 2015

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010

Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids

Violetta M Piotrowska, Wojciech J Piotrowski, Zofia Kurmanowska, et al

International Journal of Chronic Obstructive Pulmonary Disease 2010, 5:107-117

Published Date: 20 April 2010