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Development of hypertension – clinical impact of dysregulation of circadian rhythms and implications for treatment

Authors Solocinski K, Gumz M

Received 29 July 2014

Accepted for publication 5 March 2015

Published 26 June 2015 Volume 2015:5 Pages 27—35

DOI https://doi.org/10.2147/CPT.S54342

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Marc Hébert

Kristen Solocinski,1,2 Michelle L Gumz1,2

1Department of Medicine, 2Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA

Abstract: Blood pressure, like most physiological processes, exhibits a circadian pattern of variation. Disruption of the normal circadian rhythm of blood pressure is associated with end organ damage and increased risk of adverse cardiovascular outcomes. In this review, we discuss the role of the renin angiotensin aldosterone system and the molecular clock in maintaining circadian blood pressure patterns. We also consider disrupted circadian blood pressure rhythms and hypertension in distinct populations and the role of chronotherapy in the treatment of hypertension.

Keywords: clock, kidney, adrenal, aldosterone, chronotherapy, sleep

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