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Development and validation of CT imaging–based preoperative nomogram in the prediction of unfavorable high-grade small renal masses

Authors Xie H, Li G, Liu K, Wang Z, Shang Z, Liu Z, Xiong Z, Quan C, Niu Y

Received 8 September 2018

Accepted for publication 7 December 2018

Published 25 September 2019 Volume 2019:11 Pages 8731—8741

DOI https://doi.org/10.2147/CMAR.S186914

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Lu-Zhe Sun


Hui Xie,* Gang Li,* Kangkang Liu, Zhun Wang, Zhiqun Shang, Zihao Liu, Zhilei Xiong, Changyi Quan, Yuanjie Niu

Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yuanjie Niu
Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, No. 23, Pingjiang Road, Hexi District, Tianjin 300211, People’s Republic of China
Tel +86 1 520 221 6807
Email niuyuanjie68@163.com

Purpose: In recent years, there has been an increase in the incidence of small renal masses (SRMs) and nephrectomy was the standard management of this disease in the past. Currently, the use of active surveillance has been recommended as an alternative option in the case of some patients with SRMs due to its heterogenicity. However, limited studies focused on the regarding risk stratification. Therefore, in the current study, we developed a nomogram for the purpose of predicting the presence of high-grade SRMs on the basis of the patient information provided (clinical information, hematological indicators, and CT imaging data).
Patients and methods: A total of 329 patients (consisting of development and validation cohort) who had undergone nephrectomy for SRMs between January 2013 and May 2016 retrospectively were recruited for the present study. All preoperative information, including clinical predictors, hematological indicators, and CT predictors, were obtained. Lasso regression model was used for data dimension reduction and feature selection. Multivariable logistic regression analysis was applied for the establishment of the predicting model. The performance of the nomogram was assessed with respect to its calibration and discrimination properties and externally validated.
Results: The predictors used in the assessment of the nomogram included tumor size, CT tumor contour, CT necrosis, CT tumor exophytic properties, and CT collecting system oppression. Based on these parameters, the nomogram was evaluated to have an effective discrimination and calibration ability, and the C-index was found to be 0.883 after internal validation and 0.887 following external validation.
Conclusion: Based on the aforementioned findings, it can be concluded that CT imaging–based preoperative nomogram is an effective predictor of SRMs and hence can be used in the preoperative evaluation of SRMs, due to its calibration and discrimination abilities.

Keywords: renal cell carcinoma, small renal masses, SRMs, nomogram, tumor histology, CT

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