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Development and Clinical Prospects of Techniques to Separate Circulating Tumor Cells from Peripheral Blood

Authors Tian C, Xu X, Wang Y, Li D, Lu H, Yang Z

Received 4 February 2020

Accepted for publication 15 July 2020

Published 14 August 2020 Volume 2020:12 Pages 7263—7275

DOI https://doi.org/10.2147/CMAR.S248380

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Sanjeev Srivastava


Cheng Tian, Xinhua Xu, Yuke Wang, Dailong Li, Haiyan Lu, Ziwei Yang

Yichang Central People’s Hospital, First Clinical Medical College of Three Gorges University, Yichang 443000, People’s Republic of China

Correspondence: Xinhua Xu
First Clinical Medical College of Three Gorges University, Yichang Central People’s Hospital, 180 Yiling Main Road, Yichang 443000, People’s Republic of China
Email xuxinhua@medmail.com.cn

Abstract: Detection of circulating tumor cells (CTC) is an important liquid biopsy technique that has advanced considerably in recent years. To further advance the development of technology for curing cancer, several CTC technologies have been proposed by various research groups. Despite their potential role in early cancer diagnosis and prognosis, CTC methods are currently used for research purposes only, and very few methods have been accepted for clinical applications because of difficulties, including CTC heterogeneity, CTC separation from the blood, and a lack of thorough clinical validation. Although current CTC technologies have not been truly implemented, they possess high potential as future clinical diagnostic techniques for individualized cancer. Here, we review current developments in CTC separation technology. We also explore new CTC detection methods based on telomerase and nanomaterials, such as in vivo flow cytometry. In addition, we discuss the difficulties that must be overcome before CTC can be applied in clinical settings.

Keywords: circulating tumor cells, cancer, liquid biopsy, tumor metastasis, cancer diagnosis

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