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Development and Characterization of A New Dimethicone Nanoemulsion and its Application for Electronic Gastroscopy Examination

Authors Feng SM, Zhao Y, Xu Q, Li HM, Huang YX, Liu HH, Xu CB

Received 24 February 2020

Accepted for publication 18 June 2020

Published 29 July 2020 Volume 2020:15 Pages 5405—5416

DOI https://doi.org/10.2147/IJN.S251113

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang


Suo-Min Feng, 1, 2,* Ying Zhao, 3 Qing Xu, 4 Hui-Min Li, 5 Yu-Xiu Huang, 6 Huan-Huan Liu, 1 Cang-Bao Xu 1,*

1Shaanxi Key Laboratory of Ischemic Cardiovascular Disease, Xi’an Medical University, Xi’an 710021, People’s Republic of China; 2School of Pharmacy, Xi’an Medical University, Xi’an 710021, People’s Republic of China; 3School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; 4College of Life Sciences, Northwest University, Xi’an 710069, People’s Republic of China; 5Public Course Teaching Department, Shangluo Vocational and Technical College, Shangzhou, 726000, People’s Republic of China; 6Department of English, Xi’an Medical University, Xi’an 710021, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Suo-Min Feng; Cang-Bao Xu
Xi’an Medical University, No. 1, Xinwang Road, Weiyang District, Xi’an 710021, People’s Republic of China
Fax +86 29-86177539
Email fengsuomin@126.com; cangboxu@yahoo.com

Purpose: Although the effective and safe medical defoamers, dimethicone (DM) and simethicone (SM) are widely used in electronic gastroscope examination (EGE), their preparations are presented in the form of suspensions or emulsions, these are untransparent or milk-like in appearance and can easily cause misdiagnosis as a result of an unclear field of vision if the doctor does not master the amount of defoamer or operates incorrectly. At the same time, it is also difficult to wash out the camera and pipeline, due to the large oil droplets of preparations. The purpose of this study was to develop a new clear and transparent oil in water (O/W) DM nanoemulsions (DMNs) and observe the effect of application in EGE.
Methods: The oil phase was chosen for its antifoaming activity and viscosity. The emulsifier and co-emulsifier were selected according to the solubility of the oil phase in them. The water titration method was used to make the pseudoternary phase diagrams of nanoemulsions and optimize the prescription composition. DM-in-water nanoemulsion was prepared by the low energy method and evaluated for appearance, antifoaming ability, droplet size, and stability. The effect of DMNs utilized in EGEs was also observed.
Results: The optimal formulation of DMNs contained CRH-40 as an emulsifier, PEG-400 as a co-emulsifier, DM as oil phase with the viscosity of 10 mPa.s, and their proportion was 4.5:4.5:1, respectively. DMNs obtained the average particle size of 67.98 nm with the polydispersity index (PDI) of 0.332, and 57.14% defoaming rate. The result of using an EGE showed that DMNs were superior in comparison to the emulsions with regard to the defoaming effect, visual clarity, and easy cleanup.
Conclusion: DMNs were found to provide excellent visual clarity to its other preparations. The novel DMNs is a promising substitute for DM emulsions or suspensions in EGEs.

Keywords: dimethicone , simethicone , dimethicone nanoemulsions, electronic gastroscopy examination, deformer

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