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Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug

Authors Abdel Rahim S, Carter P, Elkordy AA

Received 4 December 2014

Accepted for publication 18 December 2014

Published 31 March 2015 Volume 2015:9 Pages 1843—1857

DOI https://doi.org/10.2147/DDDT.S78717

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Shu-Feng Zhou


Safwan Abdel Rahim,1,2 Paul A Carter,1 Amal Ali Elkordy1

1Department of Pharmacy, Health and Well-being, University of Sunderland, Sunderland, United Kingdom; 2Faculty of Pharmacy, Applied Science University, Amman, Jordan

Abstract: The aim of this work was to design and evaluate effervescent floating gastro-retentive drug delivery matrix tablets with sustained-release behavior using a binary mixture of hydroxyethyl cellulose and sodium alginate. Pentoxifylline was used as a highly water-soluble, short half-life model drug with a high density. The floating capacity, swelling, and drug release behaviors of drug-loaded matrix tablets were evaluated in 0.1 N HCl (pH 1.2) at 37°C±0.5°C. Release data were analyzed by fitting the power law model of Korsmeyer–Peppas. The effect of different formulation variables was investigated, such as wet granulation, sodium bicarbonate gas-forming agent level, and tablet hardness properties. Statistical analysis was applied by paired sample t-test and one-way analysis of variance depending on the type of data to determine significant effect of different parameters. All prepared tablets through wet granulation showed acceptable physicochemical properties and their drug release profiles followed non-Fickian diffusion. They could float on the surface of dissolution medium and sustain drug release over 24 hours. Tablets prepared with 20% w/w sodium bicarbonate at 50–54 N hardness were promising with respect to their floating lag time, floating duration, swelling ability, and sustained drug release profile.

Keywords: floating tablets, sodium alginate, pentoxifylline, dissolution, swelling, effervescent

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