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Depression in people with type 2 diabetes: current perspectives

Authors Darwish L, Beroncal E, Sison MV, Swardfager W

Received 1 February 2018

Accepted for publication 27 April 2018

Published 10 July 2018 Volume 2018:11 Pages 333—343

DOI https://doi.org/10.2147/DMSO.S106797

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Lina Darwish,1–4 Erika Beroncal,1–3 Ma Veronica Sison,1–3 Walter Swardfager1–4

1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; 3Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, Toronto, ON, Canada; 4Canadian Partnership for Stroke Recovery, Toronto, ON, Canada

Abstract: Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid depression in those with T2DM has been associated with adverse clinical profiles. Recognizing and addressing psychological symptoms remain significant clinical challenges in T2DM. Possible mediators of the reciprocal relationship between T2DM and depression may include physical activity levels, effectiveness of self-management, distress associated with a new T2DM diagnosis, and frailty associated with advanced diabetes duration. The latter considerations contribute to a “J-shaped” trajectory from the time of diagnosis. There remain significant challenges to screening for clinical risks associated with psychological symptoms in T2DM; poorer outcomes may be associated with major depressive episodes, isolated (eg, anhedonic), or subsyndromal depressive symptoms, depressive-like symptoms more specific to T2DM (eg, diabetes-related distress), apathy or fatigue. In this review, we discuss current perspectives on depression in the context of T2DM with implications for screening and management of these highly comorbid conditions.

Keywords: type 2 diabetes, depression, mood, complications

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