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Depression and Perceived Stress, but Not Anxiety, are Associated with Elevated Inflammation in an Obese Adult Population

Authors Zou B, Miao C, Chen J

Received 11 July 2020

Accepted for publication 13 August 2020

Published 9 September 2020 Volume 2020:13 Pages 1489—1497


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Marco Carotenuto

Bin Zou,1 Chenfang Miao,2 Jiliang Chen1

1Department of Orthopaedics, Affiliated Mindong Hospital of Fujian Medical University, Fuan City, Fu Jian 355000, People’s Republic of China; 2Department of Anesthesiology, Affiliated Mindong Hospital of Fujian Medical University, Fuan City, Fu Jian 355000, People’s Republic of China

Correspondence: Jiliang Chen Department of Orthopaedics
Affiliated Mindong Hospital of Fujian Medical University, No. 89 Heshan Road, Fuan City 355000, Fujian Province, People’s Republic of China
Tel +86 13959325972

Background: Anxiety, depression and perceived stress are risk factors for adverse health problems. Inflammation participates in the development of chronic diseases such as psychiatric disorders. This study explored the relationships between inflammatory biomarkers and depression, anxiety and perceived stress in an obese adult population.
Methods: The relationships between psychological scores and inflammatory markers were analyzed.
Results: A higher BMI was not correlated with a higher anxiety score (P=0.152); however, BMI was positively associated with a higher depression score (P< 0.001) and a higher perceived stress score (P< 0.001). Multivariate linear regression analysis revealed that in participants with BMI≥ 30 and 25≤BMI< 30, depression and perceived stress were significantly and independently associated with ICAM-1, E-selectin and CRP, but these associations were not observed in participants with BMI< 25. The anxiety score was not associated with any inflammatory marker in any group of subjects, as determined by multivariate analysis.
Conclusion: Depression and perceived stress were strongly associated with increased serum levels of pro-inflammatory markers, including ICAM-1, E-selectin and CRP, among a general obese population from the United States. These results further suggest that depression and perceived stress might also be chronic systemic inflammatory diseases.

Keywords: inflammatory markers, anxiety, depression, perceived stress, obesity

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