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Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer

Authors Ma Q, Qian W, Tao W, Zhou Y, Xue B

Received 2 April 2019

Accepted for publication 11 October 2019

Published 28 November 2019 Volume 2019:13 Pages 4021—4033

DOI https://doi.org/10.2147/DDDT.S210949

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Sukesh Voruganti


Qi Ma,1,* Wei Qian,2,* Wei Tao,2 Yanling Zhou,3 Boxin Xue2

1Department of Ultrasound, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Operation, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Wei Tao
Department of Urology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Gusu District, Suzhou City, Jiangsu Province, People’s Republic of China
Tel/Fax +86 0512-67784837
Email tw27024@163.com
Yanling Zhou
Department of Operation, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Gusu District, Suzhou City, Jiangsu Province, People’s Republic of China
Email sdfeyzyl@163.com

Aim: The aim of this study was to characterize curcumin (CUR)-loaded CD133 aptamer A15 liposomes for their antitumor activity in vitro and in vivo.
Methods: The modified CUR liposomes were prepared by the thin-film hydration technique.
Results: The particles showed spherical shape under electron microscopy with sizes Conclusion: These results indicate that A15 modified CUR liposomes are a promising candidate for antitumor drug delivery.

Keywords: CD133 aptamers, curcumin, prostate cancer, liposomes, cell viability, cellular internalization, in vivo evaluation

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