Back to Browse Journals » Eye and Brain » Volume 4

Delayed saccadic eye movements in glaucoma

Authors Kanjee R, Yücel YH, Steinbach MJ, González EG, Gupta N

Received 24 September 2012

Accepted for publication 29 October 2012

Published 27 November 2012 Volume 2012:4 Pages 63—68


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Raageen Kanjee,1 Yeni H Yücel,1,2 Martin J Steinbach,3,4 Esther G González,3,4 Neeru Gupta1,2,5

Ophthalmology and Vision Sciences, Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, 2Keenan Research Centre at the Li Ka Shing Knowledge Institute of St Michael's Hospital, 3Toronto Western Hospital, University Health Network, 4Centre for Vision Research, York University, 5Glaucoma and Nerve Protection Unit, St Michael's Hospital, Toronto, ON, Canada

Purpose: To determine whether saccadic eye movements are altered in glaucoma patients.
Patients and methods: Sixteen patients with glaucoma and 21 control subjects were prospectively studied. Patients participated in a pro-saccade step task. Saccades were recorded using a noninvasive infrared oculometric device with head-mounted target projection. Medians of saccade reaction time, duration, amplitude, and peak velocity; frequency of express saccades; and percentage of trials with direction error were recorded. t-tests were used to compare the glaucoma and age-matched control groups. A correlation analysis of saccade parameters with visual field loss was also performed.
Results: Median saccade reaction times were significantly prolonged in glaucoma patients compared with controls (220.9 ± 49.02 ms vs 192.1 ± 31.24 ms; t-test: P = 0.036). Median duration, median amplitude, and median peak velocity of saccades did not show significant differences between glaucoma and control groups (P > 0.05). Frequency of express saccades was significantly decreased in glaucoma patients compared with controls (1.75 ± 2.32 vs 7.0 ± 6.99; t-test: P = 0.007). Saccade parameters in glaucoma patients showed no significant correlation with visual field loss.
Conclusion: Saccadic eye movements are significantly delayed in patients with early, moderate, or advanced glaucoma. Determination of median saccade reaction time may offer a novel functional test to quantify visual function in glaucoma patients. Further studies are needed to determine pathological processes implicated in delayed initiation of saccades, and to assess whether alteration of saccades affects daily activities in glaucoma patients.

Keywords: visual field, latency, visual dysfunction, brain, superior colliculus, quality of life

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Shared decision-making in the People’s Republic of China: current status and future directions

Huang RC, Gionfriddo MR, Zhang LZ, Leppin AL, Ting HH, Montori VM

Patient Preference and Adherence 2015, 9:1129-1141

Published Date: 6 August 2015

Impact of noncommunicable diseases in the State of Qatar

Al-Kaabi SK, Atherton A

ClinicoEconomics and Outcomes Research 2015, 7:377-385

Published Date: 2 July 2015

Preferences of patients undergoing hemodialysis – results from a questionnaire-based study with 4,518 patients

Janssen IM, Gerhardus A, von Gersdorff GD, Baldamus CA, Schaller M, Barth C, Scheibler F

Patient Preference and Adherence 2015, 9:847-855

Published Date: 26 June 2015

Femtosecond laser-assisted implantation of complete versus incomplete rings for keratoconus treatment

Hosny M, El–Mayah E, Sidky MK, Anis M

Clinical Ophthalmology 2015, 9:121-127

Published Date: 20 January 2015

Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid

Nanda SS, An SS, Yi DK

International Journal of Nanomedicine 2015, 10:549-556

Published Date: 12 January 2015

Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals

Farazuddin M, Dua B, Zia Q, Khan AA, Joshi B, Owais M

International Journal of Nanomedicine 2014, 9:1139-1152

Published Date: 3 March 2014

Family medicine’s rapid establishment and early leadership role in Qatar’s health care system

Verjee MA, Abdulmalik MA, Fetters MD

Journal of Healthcare Leadership 2013, 5:47-52

Published Date: 12 August 2013

Subset-directed antiviral treatment of 142 herpesvirus patients with chronic fatigue syndrome

A Martin Lerner, Safedin Beqaj, James T Fitzgerald, et al

Virus Adaptation and Treatment 2010, 2:47-57

Published Date: 24 May 2010