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Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness

Authors Turkmani MG, De Boulle K, Philipp-Dormston WG

Received 13 December 2018

Accepted for publication 15 March 2019

Published 29 April 2019 Volume 2019:12 Pages 277—283

DOI https://doi.org/10.2147/CCID.S198081

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Mohammed G Turkmani,1 Koenraad De Boulle,2 Wolfgang G Philipp-Dormston3

1Derma Clinic, Riyadh, Saudi Arabia; 2Aalst Dermatology Clinic, Aalst, Belgium; 3Cologne Dermatology, Cologne, Germany

Background: Delayed reactions after facial hyaluronic acid injection are relatively rare complications. Their cause may be infectious or immune-mediated in origin, and their outbreak can be triggered, for example, by an influenza-like illness.
Objective: To describe potential adverse event of influenza like illness following dermal filler injection.
Methods: We report fourteen unusual cases of delayed hypersensitivity reaction to several brands of hyaluronic acid dermal filler following influenza like illness.
Results: Increasing evidence implicates influenza infection in the pathogenesis of late onset filler reaction.
Conclusion: Although there is a low risk of late onset adverse reaction with hyaluronic acid fillers, injecting physicians must be aware of the possible filler reaction following the influenza infection.

Keywords: fillers, hyaluronic acid, reaction, hypersensitivity, complications, influenza, infection


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