Back to Journals » Neuropsychiatric Disease and Treatment » Volume 9

Decreased white matter integrity before the onset of delusions in patients with Alzheimer's disease: diffusion tensor imaging

Authors Nakaaki S, Sato J, Torii K, Oka M, Negi A, Nakamae T, Narumoto J, Miyata J, Furukawa TA, Mimura M

Received 8 October 2012

Accepted for publication 26 November 2012

Published 27 December 2012 Volume 2013:9 Pages 25—29

DOI https://doi.org/10.2147/NDT.S38942

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Shutaro Nakaaki,1 Junko Sato,2 Katsuyoshi Torii,2 Mizuki Oka,1 Atsushi Negi,2 Takashi Nakamae,3 Jin Narumoto,3 Jun Miyata,4 Toshi A Furukawa,5 Masaru Mimura1

1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 2Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 3Department of Psychiatry, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Department of Neuropsychiatry, Kyoto University, Kyoto, Japan; 5Department of Health Promotion and Human Behavior (Cognitive-Behavioral Medicine), Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan

Background: The pathology of delusions in patients with Alzheimer's disease (AD) associated with white matter (WM) abnormalities is poorly understood. In addition, whether the abnormalities in WM integrity that underlie the delusions develop before the onset of the delusions remains unclear. In this study, we used a diffusion tensor imaging approach to examine the existence of baseline abnormalities in WM integrity in AD patients who developed delusions and AD patients who did not develop delusions.
Methods: Using the Neuropsychiatric Inventory, we identified patients with AD who exhibit delusions during a 1-year period. All the patients underwent a magnetic resonance imaging (MRI) examination at baseline. We conducted fractional anisotropy using tract-based spatial statistics software and compared the results of AD patients who developed delusions with those who did not develop delusions.
Results: Compared with the AD patients who did not develop delusions (n = 15), the AD patients who developed delusions (n = 10) exhibited two relatively large clusters and one minimal cluster of significantly lower fractional anisotropy results. The first cluster was located in the left parieto-occipital region and included several fibers: the left inferior longitudinal fasciculus, the inferior fronto-occipital fasciculus, the posterior corona radiate, and the forceps major of the corpus callosum. The second cluster was located on the body of the corpus callosum. A third minimal cluster was located on the superior temporal gyrus white matter.
Conclusion: Abnormalities in WM integrity involving several fibers may be crucial to the development of delusions in AD patients.

Keywords: Alzheimer's disease, white matter, DTI, delusions, tract-based spatial statistics

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry

Hashimoto N, Nakaaki S, Kawaguchi A, Sato J, Kasai H, Nakamae T, Narumoto J, Miyata J, Furukawa TA, Mimura M

Neuropsychiatric Disease and Treatment 2014, 10:1987-1996

Published Date: 20 October 2014

Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease

Banno K, Nakaaki S, Sato J, Torii K, Narumoto J, Miyata J, Hirono N, Furukawa TA, Mimura M, Akechi T

Neuropsychiatric Disease and Treatment 2014, 10:339-348

Published Date: 17 February 2014

Neuroanatomical abnormalities before onset of delusions in patients with Alzheimer’s disease: a voxel-based morphometry study

Nakaaki S, Sato J, Torii K, Oka M, Negi A, Nakamae T, Narumoto J, Miyata J, Furukawa TA, Mimura M

Neuropsychiatric Disease and Treatment 2013, 9:1-8

Published Date: 21 December 2012

Behavior management approach for agitated behavior in Japanese patients with dementia: a pilot study

Sato J, Nakaaki S, Torii K, Oka M, Negi A, Tatsumi H, Narumoto J, Furukawa TA, Mimura M

Neuropsychiatric Disease and Treatment 2013, 9:9-14

Published Date: 21 December 2012

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010