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Decrease of RBM4 indicates poor prognosis in patients with hepatocellular carcinoma after hepatectomy

Authors Chen J, Liu L, Xu J

Received 20 October 2016

Accepted for publication 19 November 2016

Published 11 January 2017 Volume 2017:10 Pages 339—345

DOI https://doi.org/10.2147/OTT.S125250

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang

Jian-yao Chen,1 Li-ping Liu,2 Jiang-feng Xu3

1Department of Hepatobiliary Surgery, Shaoxing Second Hospital, Shaoxing, 2Department of Surgery, Zhuzhou Clinical Institute, Central South University School of Medicine, Zhuzhou, 3Department of Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, People’s Republic of China

Abstract: RNA-binding motif 4 (RBM4) has been reported to play an important role in many human tumors such as lung cancer, breast cancer, ovarian cancer and gastric cancer by regulating alternative splicing and messenger RNA (mRNA) translation. However, little is known about the role of RBM4 in the development of hepatocellular carcinoma (HCC). This study aimed to investigate the expression of RBM4 in HCC tissues. Expression of RBM4 was detected by immunohistochemistry in 95 cases of HCC. Correlations of RBM4 expression with the overall survival and disease-free survival of HCC were also studied. Patients with high RBM4 expression had better overall survival rate and disease-free survival rate than those with low RBM4 expression (P<0.001, P=0.007, respectively). RBM4 expression, together with tumor numbers, capsular formation, vascular invasion and Barcelona clinic liver cancer (BCLC) stage, was an independent prognostic factor for overall survival rate and disease-free survival rate of HCC. Our data implicate RBM4 as a novel prognostic marker and a potential therapeutic target for HCC.

Keywords: RBM4, hepatocellular carcinoma, prognosis

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