Back to Browse Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Cytotoxicity of nickel zinc ferrite nanoparticles on cancer cells of epithelial origin

Authors Al-Qubaisi MS, Rasedee A, Flaifel MH, Ahmad SHJ, Hussein-Al-Ali S, Hussein MZ, Eid EEM, Zainal Z, Saeed M, Ilowefah M, Fakurazi S, Mohd Isa N, El Zowalaty ME

Received 5 January 2013

Accepted for publication 22 February 2013

Published 15 July 2013 Volume 2013:8(1) Pages 2497—2508

DOI http://dx.doi.org/10.2147/IJN.S42367

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Mothanna Sadiq Al-Qubaisi,1 Abdullah Rasedee,1,2 Moayad Husein Flaifel,5 Sahrim HJ Ahmad,5 Samer Hussein-Al-Ali,1 Mohd Zobir Hussein,3 Eltayeb EM Eid,6 Zulkarnain Zainal,3 Mohd Saeed,1 Muna Ilowefah,4 Sharida Fakurazi,1 Norhaszalina Mohd Isa,1 Mohamed Ezzat El Zowalaty1,7

1Institute of Bioscience, 2Faculty of Veterinary Medicine, 3Department of Chemistry, Faculty of Science, 4Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia; 5School of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Selangor, Malaysia; 6College of Pharmacy, Qassim University, Buraidah, Saudi Arabia; 7Faculty of Pharmacy, Zagazig University, Ash Sharqiyah, Egypt

Abstract: In this study, in vitro cytotoxicity of nickel zinc (NiZn) ferrite nanoparticles against human colon cancer HT29, breast cancer MCF7, and liver cancer HepG2 cells was examined. The morphology, homogeneity, and elemental composition of NiZn ferrite nanoparticles were investigated by scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The exposure of cancer cells to NiZn ferrite nanoparticles (15.6–1,000 µg/mL; 72 hours) has resulted in a dose-dependent inhibition of cell growth determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The quantification of caspase-3 and -9 activities and DNA fragmentation to assess the cell death pathway of the treated cells showed that both were stimulated when exposed to NiZn ferrite nanoparticles. Light microscopy examination of the cells exposed to NiZn ferrite nanoparticles demonstrated significant changes in cellular morphology. The HepG2 cells were most prone to apoptosis among the three cells lines examined, as the result of treatment with NiZn nanoparticles. In conclusion, NiZn ferrite nanoparticles are suggested to have potential cytotoxicity against cancer cells.

Keywords: NiZn ferrite nanoparticles, cancer cells lines, anticancer, apoptosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] View Full Text [HTML] 

 

Other article by this author:

Induction of apoptosis in cancer cells by NiZn ferrite nanoparticles through mitochondrial cytochrome C release

Al-Qubaisi MS, Rasedee A, Flaifel MH, Ahmad SH, Hussein-Al-Ali S, Hussein MZ, Zainal Z, Alhassan FH, Taufiq-Yap YH, Eid EEM, Arbab IA, Al-Asbahi BA, Webster TJ, El Zowalaty ME

International Journal of Nanomedicine 2013, 8:4115-4130

Published Date: 30 October 2013

Readers of this article also read:

Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane

Yan MN, Zhang ZG, Cui SM, Lei M, Zeng K, Liao YH, Chu WJ, Deng YH, Zhao CS

International Journal of Nanomedicine 2014, 9:4867-4878

Published Date: 21 October 2014

Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma

Inoue K, Shiokawa M, Fujimoto T, Tomita G

Clinical Ophthalmology 2014, 8:1179-1183

Published Date: 19 June 2014

Antioxidative nanofullerol prevents intervertebral disk degeneration

Yang X, Jin L, Yao L, Shen FH, Shimer AL, Li X

International Journal of Nanomedicine 2014, 9:2419-2430

Published Date: 15 May 2014

Why are you here? Needs analysis of an interprofessional health-education graduate degree program

Cable C, Knab M, Tham KY, Navedo DD, Armstrong E

Advances in Medical Education and Practice 2014, 5:83-88

Published Date: 11 April 2014

Treatment selection and experience in multiple sclerosis: survey of neurologists

Hanson KA, Agashivala N, Wyrwich KW, Raimundo K, Kim E, Brandes DW

Patient Preference and Adherence 2014, 8:415-422

Published Date: 3 April 2014

Synthesis, characterization, and evaluation of paclitaxel loaded in six-arm star-shaped poly(lactic-co-glycolic acid)

Chen Y, Yang Z, Liu C, Wang C, Zhao S, Yang J, Sun H, Zhang Z, Kong D, Song C

International Journal of Nanomedicine 2013, 8:4315-4326

Published Date: 7 November 2013

Evaluation of corneal changes after myopic LASIK using the Pentacam®

Khairat YM, Mohamed YH, Moftah IA, Fouad NN

Clinical Ophthalmology 2013, 7:1771-1776

Published Date: 9 September 2013

Visual and refractive outcomes after implantation of a fully diffractive trifocal lens

Cochener B, Vryghem J, Rozot P, Lesieur G, Heireman S, Blanckaert JA, Van Acker E, Ghekiere S

Clinical Ophthalmology 2012, 6:1421-1427

Published Date: 3 September 2012