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Cytoskeleton and Golgi-apparatus interactions: a two-way road of function and structure

Authors Egea G, Serra-Peinado C, Gavilan MP, Rios RM

Received 3 October 2014

Accepted for publication 2 December 2014

Published 22 January 2015 Volume 2015:7 Pages 37—54

DOI https://doi.org/10.2147/CHC.S57108

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Denis Wirtz


Gustavo Egea,1 Carla Serra-Peinado,1 María P Gavilan,2 Rosa M Rios2

1Departament de Biologia Cel·lular, Immulogia i Neurociències, Facultat de Medicina and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain; 2Departamento de Señalización Celular, CSIC-Centro Andaluz de Biomedicina y Medicina Regenerativa (CABIMER), Seville, Spain

Abstract: The Golgi apparatus is the result of a complex and dynamic interaction between a large variety of molecules that determine its architecture, protein and lipid transports, and those that integrate signals from outside and inside the cell. The cytoskeleton facilitates the functional integration of all these processes. Association and coordination between microtubules and actin filaments, as well as their respective binding and regulatory proteins, are clearly necessary for Golgi structure and function. Protein sorting, membrane fission and fusion, and the motion of Golgi-derived transport carriers are all affected by both cytoskeleton elements.

Keywords: cytoskeleton, Golgi apparatus, membrane trafficking, secretory pathway, actin, microtubules

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