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Cytomembranic PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma

Authors Zheng L, Cao C, Cheng G, Hu Q, Chen X

Received 19 September 2017

Accepted for publication 17 October 2017

Published 16 November 2017 Volume 2017:10 Pages 5483—5487

DOI https://doi.org/10.2147/OTT.S152007

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 4

Editor who approved publication: Dr Yao Dai


Video abstract presented by Xiaozhong Chen.

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Linfeng Zheng,1,* Caineng Cao,2,3,* Guoping Cheng,1 Qiaoying Hu,2,3 Xiaozhong Chen2,3

1Department of Pathology, 2Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, 3Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, People’s Republic of China

*These authors contributed equally to this work

Background and objective: The aim of this study was to evaluate the expression of cytomembranic programmed death-ligand 1 (PD-L1) and its clinical significance in locoregionally advanced nasopharyngeal carcinoma (NPC).
Patients and methods: Formalin-fixed, paraffin-embedded tissue biopsies from 85 patients with histological diagnosis of locoregionally advanced NPC treated with radical intensity-modulated radiotherapy and concurrent cisplatin-based chemotherapy were studied. By using immunohistochemistry staining, expressions of cytomembranic PD-L1 on tumor cells were detected.
Results:
After a median follow-up duration of 65.8 months, 7 (8.2%), 5 (5.9%), and 5 (5.9%) patients suffered from local failure, regional failure, and distant metastases, respectively. The 5-year local failure-free survival, regional failure-free survival, distant failure-free survival, and overall survival (OS) rates were 90.9%, 94.8%, 94.0%, and 92.2%, respectively. Our results revealed that a high expression of cytomembranic PD-L1 was correlated with shorter OS (5y-OS: 82.5% vs 97.6%, P=0.022). In the multivariate analysis, only the cytomembranic PD-L1 was an independent prognostic factor for OS (hazard ratio: 6.176, 95% confidence interval, 1.166–32.710, P=0.032).
Conclusion: Cytomembranic PD-L1 expression levels correlated with OS in locoregionally advanced NPC. Agreement between different methods is needed for further application of PD-L1 biomarker assays in NPC.

Keywords: nasopharyngeal carcinoma, programmed death-ligand 1, PD-L1, prognosis, overall survival
 

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