Back to Journals » Neuropsychiatric Disease and Treatment » Volume 14

Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease

Authors Kose Ozlece H, Findik Guvendi G, Huseyinoglu N, Ehi Y, Kivrak Y

Received 21 November 2017

Accepted for publication 26 May 2018

Published 31 July 2018 Volume 2018:14 Pages 1901—1906


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Hatice Kose Ozlece,1 Gulname Findik Guvendi,2 Nergiz Huseyinoglu,1 Yusuf Ehi,3 Yuksel Kivrak4

1Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey; 2Department of Pathology, Medical Faculty, Kafkas University, Kars, Turkey; 3Department of Neurology, Medical Faculty, Kafkas University, Kars, Turkey; 4Department of Psychiatry, Medical Faculty, Kafkas University, Kars, Turkey

Background: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases. Recent studies have sought to identify precursor symptoms of AD and PD that occur before the onset of the disease. We evaluated changes in the oral mucosa of patients with AD and PD using a stereological method.
Patients and methods: The study included 29 patients with AD, 30 patients with idiopathic PD, and 30 healthy volunteers. Brush biopsies were obtained from all participants, and the nucleator method was used to estimate the volume of cells obtained from the buccal mucosa.
Results: Cytomorphometric analysis revealed that the nuclear volume was 484.39±117.10 µm3 in the AD group, 509.71±132.26 µm3 in PD patients, and 509.30±100.21 µm3 in the control group. The cytoplasmic volume was 115,456.60±30,664.98 µm3 in the AD group, 103,097.93±25,034.65 µm3 in PD patients, and 109,528.45±28,381.43 µm3 in the control group. The nuclear and cytoplasmic volumes were not significantly different among groups (P>0.05).
Conclusion: The cytomorphometric analysis revealed no significant differences in the cytoplasmic and nuclear volumes of buccal cells obtained from patients with AD and PD and healthy volunteers.

Alzheimer’s disease, Parkinson’s disease, exfoliative cytology, stereology, oral mucosa

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]