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Cyclic vomiting syndrome: diagnostic approach and current management strategies

Authors Hayes WJ, VanGilder D, Berendse J, Lemon MD, Kappes JA

Received 12 October 2017

Accepted for publication 5 January 2018

Published 26 February 2018 Volume 2018:11 Pages 77—84

DOI https://doi.org/10.2147/CEG.S136420

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Koulaouzidis


William J Hayes,1 Deidra VanGilder,2 Joseph Berendse,3 Michael D Lemon,3 John A Kappes4

1Department of Pharmacy Practice, South Dakota State University, Regional Health Medical Clinic, Rapid City, SD, USA; 2South Dakota State University, College of Pharmacy and Allied Health Professions, Brown Clinic, Watertown, SD, USA; 3Department of Pharmacy Practice, South Dakota State University, College of Pharmacy and Allied Health Professions, VA Black Hills Health Care System, Fort Meade, SD, USA; 4Department of Pharmacy Practice, South Dakota State University, College of Pharmacy and Allied Health Professions, Rapid City Regional Hospital, Rapid City, SD, USA

Abstract: Cyclic vomiting syndrome (CVS) is a disorder characterized by episodes of nausea and vomiting lasting for 1–5 days followed by asymptomatic periods. The etiology of CVS is unknown, but it shares similar characteristics to migraine headaches. CVS is generally classified as having four phases: prodromal, acute/vomiting/hyperemesis, recovery, and remission/interepisodic. Current management strategies include trigger avoidance, abortive and prophylactic medication therapies, and supportive care. The goal of therapy for the remission phase is prophylaxis of further episodes. Antidepressant, antiepileptic, and antimigraine medications show an overall reduction or remission of CVS symptoms in more than 70% of patients. This article provides a summary of diagnostic strategies and reviews current management strategies for CVS.

Keywords: cyclic vomiting syndrome, emesis, hyperemesis, vomiting, CVS

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