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CXCR3 is a prognostic marker and a potential target for patients with solid tumors: a meta-analysis

Authors Zhang Y, Xu L, Peng M

Received 18 November 2017

Accepted for publication 16 January 2018

Published 27 February 2018 Volume 2018:11 Pages 1045—1054

DOI https://doi.org/10.2147/OTT.S157421

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Ingrid Espinoza


Yang Zhang,1 Linjuan Xu,2 Minggang Peng2

1Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Objective: To deeply verify the clinical significance of CXCR3 in prediction of cancer patients’ prognosis.
Data sources: We performed a meta-analysis including 12 studies searched from PubMed, Web of Science, Embase, and Cochrane databases. A total of 1,751 patients were used to analyze the association between CXCR3 and patients’ prognosis, based on either overall survival or time to tumor progression.
Study selection: Studies evaluating CXCR3 expression for predicting prognosis in human solid tumors were included.
Results: It showed that patients with higher expression of CXCR3 had significantly shorter OS (pooled hazard ratio =2.315, 95% CI: 1.162–4.611, P=0.017). In addition, higher CXCR3 expression was associated with distant metastasis (yes vs no: pooled relative ratio [RR] =1.828, 95% CI: 1.140–2.931, P=0.012) in solid tumors and indicated advanced tumor stage (III/IV vs I/II, RR =2.656, 95% CI: 1.809–3.900, P<0.001) and lymph node metastasis (yes vs no: RR =2.28, 95% CI: 1.61–3.25, P<0.001) in colorectal cancer.
Conclusion: Our study highlights the role of CXCR3 as a potential prognostic marker and a promising therapeutic target in solid tumors.

Keywords: CXCR3, meta-analysis, solid tumor, prognostic marker, overall survival
 

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