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Current Understanding of Nasal Epithelial Cell Mis-Differentiation

Authors Scherzad A, Hagen R, Hackenberg S

Received 7 November 2019

Accepted for publication 4 December 2019

Published 13 December 2019 Volume 2019:12 Pages 309—317

DOI https://doi.org/10.2147/JIR.S180853

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ning Quan


Agmal Scherzad, Rudolf Hagen, Stephan Hackenberg

Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, Germany

Correspondence: Agmal Scherzad
Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Julius Maximilian University of Wuerzburg, Würzburg 97080, Germany
Email Scherzad_A@ukw.de

Abstract: The functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The following review article focuses on the aspects of epithelial mis-differentiation, in particular with respect to nasal mucosal barrier function, epithelial immunogenicity, nasal epithelial–mesenchymal transition and nasal microbiome.

Keywords: nasal mucosal barrier function, tight junction, epithelial–mesenchymal transition, microbiome

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