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Current Understanding of Circular RNAs in Gastric Cancer

Authors Tang X, Zhu J, Liu Y, Chen C, Liu T, Liu J

Received 14 July 2019

Accepted for publication 15 November 2019

Published 13 December 2019 Volume 2019:11 Pages 10509—10521

DOI https://doi.org/10.2147/CMAR.S223204

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Xueqiong Zhu


Xiaohuan Tang, Jiaming Zhu, Yuanda Liu, Chao Chen, Tianzhou Liu, Jingjing Liu

Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin, People’s Republic of China

Correspondence: Jingjing Liu
Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Jilin University, Changchun, Jilin 130041, People’s Republic of China
Tel +86-431-81136210
Email jingjingstarone@163.com

Abstract: Gastric cancer (GC) is the third most common cause of cancer-related death worldwide. Advanced diagnosis and high rates of relapse and metastasis are associated with the poor prognosis of this disease. GC has a complex etiopathogenesis of which the underlying mechanisms remain to be explored. Studies on circular RNAs (circRNAs), noncoding RNAs that may be potential targets in GC, have made substantial progress over the past few years. CircRNAs exert important effects on the onset and progression of GC. Hence, this article aims to summarize the findings of recent studies of circRNAs related to GC and to describe the underlying mechanisms and potential applications. The findings indicate that circRNAs participate in GC regulation, proliferation, invasion, and metastasis through regulating microRNAs, proteins, genes, and signaling pathways. In addition, dysregulated circRNAs may be used as novel diagnostic and prognostic biomarkers or therapeutic targets. This review is expected to facilitate a better understanding of GC, and it suggests novel circRNA-based methods to inhibit or prevent GC.

Keywords: gastric cancer, circular RNA, biomarkers, diagnosis, prognosis


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