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Current trends in needle-free jet injection: an update

Authors Barolet D, Benohanian A

Received 16 January 2018

Accepted for publication 8 March 2018

Published 1 May 2018 Volume 2018:11 Pages 231—238

DOI https://doi.org/10.2147/CCID.S162724

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Daniel Barolet,1,2 Antranik Benohanian3

1RoseLab Skin Optics Research Laboratory, Laval, QC, Canada; 2MUHC Dermatology Service, Department of Medicine, McGill University, Montreal, QC, Canada; 3CHUM Service de Dermatologie, Université de Montréal, Montréal, QC, Canada

Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin.
Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use.
Methods: A review of the literature was performed with no limits placed on publication date.
Results: Needleless injectors not only reduce pain during drug delivery but also confine the drug more evenly in the dermis. Understanding skin properties of the injection site is a key factor to obtain optimal results as well as setting the right parameters of the jet injector. Until the advent of disposable jet injectors/cartridges, autoclaving of the injector remains the only reliable method to eliminate the risk of infection. Needle-free intradermal injection using corticosteroids and/or local anesthetics is well documented with promising indications being developed.
Limitations: Limitations of the review include low-quality evidence, small sample sizes, varying treatment parameters, and publication bias.
Conclusion: New developments may help reconsider the use of jet injection technology. Future studies should focus on measurable optimized parameters to insure a safe and effective outcome.

Keywords: needle free, injector, jet injection, xylocaine, triamcinolone, PDT

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