Back to Journals » Pediatric Health, Medicine and Therapeutics » Volume 4

Current treatment options for the management of patent ductus arteriosus

Authors Takeuchi K, Hirota A, Minegishi S, Kobayashi J, Tsuchiya L

Received 24 December 2012

Accepted for publication 12 February 2013

Published 26 March 2013 Volume 2013:4 Pages 23—27


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Koh Takeuchi,1 Atsushi Hirota,2 Sachito Minegishi,1 Jotaro Kobayashi,1 Keiji Tsuchiya3

1Division of Cardiovascular Surgery, 2Department of Neonatology, 3Department of Pediatrics, Japanese Red Cross Medical Center, Shibuya, Tokyo, Japan

Abstract: Pharmacological and/or surgical closure of a hemodynamically significant patent ductus arteriosus (PDA) in the very premature infant has been the standard of care over the past few decades. However, the rationale for closure of PDA has recently been challenged. In this article, three ways of approaching the closure of PDA including pharmacological treatment, catheter intervention, and surgical intervention, are reviewed in detail. In addition, the different treatment strategies applied in clinical care are evaluated with a focus on the discussion of the available evidence of PDA treatment in the literature.

Keywords: patent ductus arteriosus, premature infant, treatment option

Creative Commons License © 2013 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.