Back to Journals » International Journal of Nanomedicine » Volume 11

Current status and perspectives in atomic force microscopy-based identification of cellular transformation

Authors Dong C, Hu X, Dinu CZ

Received 2 January 2016

Accepted for publication 18 February 2016

Published 17 May 2016 Volume 2016:11 Pages 2107—2118

DOI https://doi.org/10.2147/IJN.S103501

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster


Chenbo Dong, Xiao Hu, Cerasela Zoica Dinu

Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV, USA

Abstract: Understanding the complex interplay between cells and their biomechanics and how the interplay is influenced by the extracellular microenvironment, as well as how the transforming potential of a tissue from a benign to a cancerous one is related to the dynamics of both the cell and its surroundings, holds promise for the development of targeted translational therapies. This review provides a comprehensive overview of atomic force microscopy-based technology and its applications for identification of cellular progression to a cancerous phenotype. The review also offers insights into the advancements that are required for the next user-controlled tool to allow for the identification of early cell transformation and thus potentially lead to improved therapeutic outcomes.

Keywords: atomic force microscopy (AFM), nanoindentation, malignant transformation, cancerous phenotype, bio-nano-mechanical signature

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]