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Current progress toward vaccines against Toxoplasma gondii

Authors Garcia JL, Innes EA, Katzer F

Received 13 November 2013

Accepted for publication 21 February 2014

Published 16 April 2014 Volume 2014:4 Pages 23—37


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

João Luis Garcia,1 Elisabeth A Innes,2 Frank Katzer2

1Department of Preventative Veterinary Medicine, Center of Agricultural Science, State University of Londrina, Parana, Brazil; 2Moredun Research Institute, Pentlands Science Park, Edinburgh, Scotland

Abstract: Toxoplasma gondii is an intracellular protozoan parasite that can infect many warm-blooded animal species and humans. Despite substantial knowledge of the biology, epidemiology, and host-pathogen interactions of T. gondii, there are still very few effective control strategies to prevent oocyst shedding in cats, tissue cysts in livestock for consumption, and infection and disease in humans. This article reviews current progress and targets for vaccination against T. gondii.

Keywords: toxoplasmosis, vaccination, livestock animals, cats, immune response, organelles

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