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Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management

Authors Palimeri S, Palioura E, Diamanti-Kandarakis E

Received 27 April 2015

Accepted for publication 21 July 2015

Published 1 September 2015 Volume 2015:8 Pages 415—426

DOI https://doi.org/10.2147/DMSO.S63089

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Ming-Hui Zou


Sotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-Kandarakis

Endocrine Unit, Medical School University of Athens, Athens, Greece

*These authors contributed equally to this work

Abstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.

Keywords: AGEs, dietary glycotoxins, dietary restriction, PCOS, MSR-1, RAGE

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