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Current Insights Into The Management Of Discoid Lupus Erythematosus

Authors Company-Quiroga J, Alique-García S, Romero-Maté A

Received 9 April 2019

Accepted for publication 18 September 2019

Published 3 October 2019 Volume 2019:12 Pages 721—732


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Jaime Company-Quiroga,* Sergio Alique-García,* Alberto Romero-Maté

Dermatology Department, Fuenlabrada Univesity Hospital, Madrid, Spain

*These authors contributed equally to this work

Correspondence: Jaime Company-Quiroga
Dermatology Department, Fuenlabrada Univesity Hospital, Camino del Molino 2, Fuenlabrada, Madrid 28942, Spain

Abstract: Discoid lupus erythematosus is the most disfiguring and common presentation of chronic cutaneous lupus erythematosus. Although most patients will respond to lifestyle measures and topical treatment, a non-negligible number of patients will require systemic and physical therapy, either alone or in combination. We performed a review of the available evidence on the discoid lupus erythematosus treatment. Lifestyle measures and topical treatment (corticosteroids and topical calcineurin inhibitors) remain the therapeutic strategies with the highest evidence level. Within systemic treatment approaches, antimalarial drugs are still the first-line therapy, while other systemic and physical therapies have highly variable evidence. Hence, we propose a therapeutic algorithm based on the strength of recommendations of the different treatment modalities, focusing on the refractory disease.

Keywords: discoid lupus erythematosus, cutaneous lupus erythematosus, disease management

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