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Current concepts in the management of hepatopulmonary syndrome

Authors Vincent Ho

Published 10 October 2008 Volume 2008:4(5) Pages 1035—1041


Review by Single-blind

Peer reviewer comments 4

Vincent Ho

School of Medicine, James Cook University, Cairns, Queensland, Australia

Abstract: The hepatopulmonary syndrome is characterized as the triad of liver disease, pulmonary gas exchange abnormalities leading to arterial deoxygenation and evidence of intrapulmonary vascular dilatations. This review summarizes the pathological mechanisms leading to pulmonary vascular changes in hepatopulmonary syndrome. The role of the three currently used diagnostic imaging modalities of contrast-enhanced echocardiography, perfusion lung scanning and pulmonary arteriography that identify the presence of intrapulmonary vascular abnormalities are reviewed. Liver transplantation is considered to be the definitive treatment of hepatopulmonary syndrome with often successful reversal of hypoxaemia, however other treatments have been trialed. This review further appraises the evidence for the use of pharmacological agents and the role of radiological interventions in hepatopulmonary syndrome.

Keywords: hepatopulmonary syndrome, liver cirrhosis, lung diseases

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