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Current and emerging treatments for the management of myasthenia gravis

Authors Sathasivam S

Published 22 July 2011 Volume 2011:7 Pages 313—323

DOI https://doi.org/10.2147/TCRM.S14015

Review by Single-blind

Peer reviewer comments 2


Sivakumar Sathasivam
The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool, UK

Abstract: Myasthenia gravis is an autoimmune neuromuscular disorder. There are several treatment options, including symptomatic treatment (acetylcholinesterase inhibitors), short-term immunosuppression (corticosteroids), long-term immunosuppression (azathioprine, cyclosporine, cyclophosphamide, methotrexate, mycophenolate mofetil, rituximab, tacrolimus), rapid acting short-term immunomodulation (intravenous immunoglobulin, plasma exchange), and long-term immunomodulation (thymectomy). This review explores in detail these different treatment options. Potential future treatments are also discussed.

Keywords: acetylcholinesterase inhibition, immunosuppression, immunomodulation, thymectomy

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