Back to Journals » Pediatric Health, Medicine and Therapeutics » Volume 4

Current and emerging treatment options for pediatric eosinophilic esophagitis

Authors Elitsur Y

Received 3 July 2013

Accepted for publication 4 August 2013

Published 2 September 2013 Volume 2013:4 Pages 101—107

DOI https://doi.org/10.2147/PHMT.S40810

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Yoram Elitsur

Department of Pediatrics, Gastroenterology Division, Marshall University, John C Edwards School of Medicine, Huntington, WV, USA

Abstract: Eosinophilic esophagitis is a new clinicopathologic disorder and has been recognized as a chronic disease in children and adults. The disease is associated with environmental and food allergies, but the exact pathophysiology has not yet been discovered. Epidemiological studies showed a global distribution of the disease and an uneven geographic distribution within the United States where the northeastern states had a higher rate of prevalence compared to the western states. Studies have shown that there are multiple confounding factors that affect the phenotypic characteristics of the disease which may include place of residence (rural versus urban), ethnicity, race, and genetics, among others. Clinical presentation may be different between adult and pediatric patients, but the endoscopic and histological characteristics of the disease are very similar between those groups. The pathophysiology of the disease has not yet been established, but the mucosal immune system, especially the pathway involving the eosinophil lineage, has been suggested as taking a major role in the pathophysiology. Accordingly, the suggested therapeutic options for this disease include elimination diets, steroids, and anti-eosinophil medications. Unfortunately, those treatment options are limited by their efficacy and the side effects associated with their chronic use. In the current review, we describe the characteristics of eosinophilic esophagitis and present the available treatments and their pitfalls. We also speculate on the future development of new treatment for this chronic disease.

Keywords: eosinophilic esophagitis, treatment, children, review

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]