Back to Journals » Breast Cancer: Targets and Therapy » Volume 4

Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy

Authors Abramson R, Arlinghaus, Weis, Li, Dula, Chekmenev E, Smith, Miga, Abramson, Yankeelov

Received 12 July 2012

Accepted for publication 4 September 2012

Published 11 October 2012 Volume 2012:4 Pages 139—154


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Richard G Abramson,1,2,9 Lori R Arlinghaus,1,2 Jared A Weis,1,2 Xia Li,1,2 Adrienne N Dula,1,2 Eduard Y Chekmenev,1–4,9 Seth A Smith,1–3,5 Michael I Miga,1–3,6 Vandana G Abramson,7,9 Thomas E Yankeelov1–3,5,8,9

Institute of Imaging Science, 2Department of Radiology and Radiological Sciences, 3Department of Biomedical Engineering, 4Department of Biochemistry, 5Department of Physics, 6Department of Neurosurgery, 7Department of Medical Oncology, 8Department of Cancer Biology, 9Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville,TN, USA

Abstract: Reliable early assessment of breast cancer response to neoadjuvant therapy (NAT) would provide considerable benefit to patient care and ongoing research efforts, and demand for accurate and noninvasive early-response biomarkers is likely to increase. Response assessment techniques derived from quantitative magnetic resonance imaging (MRI) hold great potential for integration into treatment algorithms and clinical trials. Quantitative MRI techniques already available for assessing breast cancer response to neoadjuvant therapy include lesion size measurement, dynamic contrast-enhanced MRI, diffusion-weighted MRI, and proton magnetic resonance spectroscopy. Emerging yet promising techniques include magnetization transfer MRI, chemical exchange saturation transfer MRI, magnetic resonance elastography, and hyperpolarized MR. Translating and incorporating these techniques into the clinical setting will require close attention to statistical validation methods, standardization and reproducibility of technique, and scanning protocol design.

Keywords: treatment response, presurgical treatment, neoadjuvant chemotherapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]