Back to Journals » Drug Design, Development and Therapy » Volume 14

Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin

Authors Shabeeb D, Musa AE, Abd Ali HS, Najafi M

Received 29 May 2020

Accepted for publication 24 July 2020

Published 5 August 2020 Volume 2020:14 Pages 3159—3163

DOI https://doi.org/10.2147/DDDT.S265228

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Lymperopoulos


Dheyauldeen Shabeeb,1,2 Ahmed Eleojo Musa,3 Hayder Shabeeb Abd Ali,4 Masoud Najafi5

1Department of Physiology, School of Medicine, University of Misan, Misan, Iraq; 2Misan Radiotherapy Center, Ministry of Health, Misan, Iraq; 3Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Physiology, Ministry of Education, Misan, Misan, Iraq; 5Department of Radiology and Nuclear Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Correspondence: Dheyauldeen Shabeeb
Department of Physiology, School of Medicine, University of Misan, Misan, Iraq
Tel +9647717879332
Email zahamtop5@gmail.com
Ahmed Eleojo Musa
Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran
Tel +989012843317
Email musahmed@yahoo.com

Objective: Side-effects to normal tissues reduce the therapeutic window of radiotherapy. During radiotherapy, the skin is inevitably exposed to doses of ionizing radiation, leading to varying degrees of skin damage. Natural antioxidants have been explored for their radioprotective potentials. Thus, the present study aimed to investigate the protective effect of curcumin against radiotherapy-induced oxidative damage to the skin.
Methods: Forty rats were divided into four groups as follows: vehicle control (without irradiation or drug treatment), treatment with 150 mg/kg curcumin, 10 Gy single dose irradiation only, and 150 mg/kg curcumin plus 10 Gy radiation (RC). In the treatment groups, each rat was treated orally with 150 mg/kg curcumin 1 day before irradiation to 3 consecutive days after irradiation. Weeks 1, 2, or 4 after irradiation, all rats were sacrificed and their skin tissues collected and frozen at − 80°C for the determination of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity in skin tissues.
Results: Radiotherapy-induced oxidative injury to the skin was evidenced by elevated MDA levels as well as depleted CAT, SOD, and GSH-Px activities. However, the administration of curcumin before and after irradiation prevented radiotherapy-induced oxidative damage by significantly elevating the activities of antioxidant enzymes.
Conclusion: From the findings of the present study, curcumin showed potential for protection against radiotherapy-induced oxidative injury to the skin. However, future studies are required to evaluate its clinical efficacy.

Keywords: curcumin, radiotherapy, ionizing radiation, radiation protection, skin

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]