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Cubosome nanoparticles potentiate immune properties of immunostimulants

Authors Liu Z, Luo L, Zheng S, Niu Y, Bo R, Huang Y, Xing J, Li Z, Wang D

Received 12 April 2016

Accepted for publication 25 May 2016

Published 29 July 2016 Volume 2016:11 Pages 3571—3583

DOI https://doi.org/10.2147/IJN.S110406

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Zhenguang Liu, Li Luo, Sisi Zheng, Yale Niu, Ruonan Bo, Yee Huang, Jie Xing, Zhihua Li, Deyun Wang

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China

Abstract: Cubosomes have been explored as drug and antigen carriers in the past few years. A few reports have described that cubosomes can enhance the ability of immunostimulants to generate strong immune responses. Polysaccharide (PS), an immunostimulant, has been reported to be a promising adjuvant for vaccines. Herein, we incorporated PS into cubosomes to generate PS–cubosome (Cub-PS) nanoparticles, and Cub-PS was characterized by small-angle X-ray scattering scattering and cryo-field emission scanning electron microscopy. The immunological activity of Cub-PS was compared with that of Cub and PS. The results demonstrated that Cub-PS elicited more potent immune responses than Cub or PS alone. The enhanced immune responses might be attributed to the promotion of antigen transport into draining lymph nodes and efficient dendritic cell activation and memory T-helper cell differentiation in draining lymph nodes. Overall, these findings indicate that cubosomes have the potential to enhance the ability of immunostimulants to generate an immune response.

Keywords: cubosomes, polysaccharides, cryo-FESEM, lymph nodes, dendritic cells, memory T-helper cells

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