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Crystallization after intravitreal ganciclovir injection

Authors Choopong P, Tesavibul N, Rodanant

Published 14 July 2010 Volume 2010:4 Pages 709—711


Review by Single-blind

Peer reviewer comments 3

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Department of Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok, Thailand

Purpose: To report crystal formation as a complication of intravitreal ganciclovir injection.

Patients and methods: A 73-year-old female patient with unilateral cytomegalovirus retinitis was treated with intravitreous ganciclovir (4 mg/0.04 mL).

Results: After the intravitreal injection, sudden crystallization was observed in the vitreous. The patient experienced marked reduction in visual acuity and increased intraocular pressure. Despite aqueous paracenthesis and pars plana vitrectomy, optic atrophy was observed and her visual acuity remained unimproved after 12 months.

Conclusion: Crystal formation can occur as a complication of intravitreal ganciclovir injection. Associated retinal and optic nerve damage was found which results in permanent visual morbidity.

Keywords: ganciclovir, intravitreal injection, intraocular, CMV, toxicity

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