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Critical evaluation of ramucirumab in the treatment of advanced gastric and gastroesophageal cancers

Authors ElHalawani H, Abdel-Rahman O

Received 5 May 2015

Accepted for publication 18 June 2015

Published 28 July 2015 Volume 2015:11 Pages 1123—1132

DOI https://doi.org/10.2147/TCRM.S71045

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 4

Editor who approved publication: Professor Garry Walsh

Video abstract presented by Omar Abdel-Rahman.

Views: 412

Hesham ElHalawani, Omar Abdel-Rahman

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Abstract: Gastric (GC) and gastroesophageal junction (GEJ) cancers are two global health problems with a relatively high mortality, particularly in the advanced stage. Inhibition of angiogenesis is now contemplated as a classic treatment preference for myriad tumor types encompassing renal cell carcinoma, non-small cell lung cancer, colorectal cancer, glioblastoma, and ovarian cancer, among others. Bevacizumab and ramucirumab have been widely investigated in GC and GEJ cancer, with some controversy about their therapeutic role. Ramucirumab is a monoclonal antibody for vascular endothelial growth factor receptor-2, with demonstrated activity both as a monotherapy and as a part of combination strategy in the management of advanced GC/GEJ cancer. In this review article, we present a critical evaluation of the preclinical and clinical data underlying the use of this drug in this indication. Moreover, we provide a spotlight on the future perspectives in systemic therapy for advanced GC/GEJ cancer.

Keywords: ramucirumab, gastric cancer, gastroesophageal cancer

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