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Critical evaluation of biodegradable polymers used in nanodrugs

Authors Marin E, Briceño MI, Caballero-George C

Received 25 April 2013

Accepted for publication 24 May 2013

Published 19 August 2013 Volume 2013:8(1) Pages 3071—3091

DOI https://doi.org/10.2147/IJN.S47186

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Edgar Marin,1–3 Maria Isabel Briceño,2 Catherina Caballero-George1

1Unit of Pharmacology, Center of Biodiversity and Drug Discovery, Institute of Scientific Research and High Technology Services, 2Nano Dispersions Technology, Panama, Republic of Panama; 3Department of Biotechnology, Archaria Nagarjuna University, Guntur, India

Abstract: Use of biodegradable polymers for biomedical applications has increased in recent decades due to their biocompatibility, biodegradability, flexibility, and minimal side effects. Applications of these materials include creation of skin, blood vessels, cartilage scaffolds, and nanosystems for drug delivery. These biodegradable polymeric nanoparticles enhance properties such as bioavailability and stability, and provide controlled release of bioactive compounds. This review evaluates the classification, synthesis, degradation mechanisms, and biological applications of the biodegradable polymers currently being studied as drug delivery carriers. In addition, the use of nanosystems to solve current drug delivery problems are reviewed.

Keywords: biodegradable polymers, nanoparticles, drug delivery, cellular uptake, biomedical applications

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