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Critical appraisal of the role of everolimus in advanced neuroendocrine tumors of pancreatic origin

Authors Mulet-Margalef, Capdevila J

Received 20 June 2012

Accepted for publication 25 July 2012

Published 27 September 2012 Volume 2012:2 Pages 29—37

DOI https://doi.org/10.2147/GICTT.S24826

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Núria Mulet-Margalef, Jaume Capdevila

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain

Abstract: For many years, the treatment of advanced pancreatic neuroendocrine tumors (pNETs) has been limited almost entirely to somatostatin analogs and streptozocin-based chemotherapy, with modest benefit. Increasing knowledge of the biologic features of pNETs has allowed the design of molecular-based clinical trials, which have taken a step forward in the management of these tumors. In this review, we discuss the molecular rationale for the development of everolimus for patients with advanced pNETs, critically review the clinical data obtained by the main studies in this setting, and discuss essential considerations based on recent findings in pNET biology for future drug development involving the phosphatidylinositol 3' kinase-AKT-mTOR pathway.

Keywords: pancreatic neuroendocrine tumors, everolimus, targeted therapies

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