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Critical appraisal of loteprednol ointment, gel, and suspension in the treatment of postoperative inflammation and pain following ocular and corneal transplant surgery

Authors Pirouzian A, Craven ER

Received 9 September 2013

Accepted for publication 24 October 2013

Published 10 February 2014 Volume 2014:8 Pages 379—387

DOI https://doi.org/10.2147/OPTH.S30278

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Amir Pirouzian,1,2 E Randy Craven1,2

1Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 2Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA

Purpose: To review comprehensively the available peer-reviewed published articles in the literature on loteprednol suspension, gel, and ointment in the treatment of ocular inflammation and pain following ocular surgery.
Methods: We conducted a PubMed literature search review of all published articles on keywords associated with loteprednol etabonate and ocular surgery.
Results: A total of 59 peer-reviewed articles were found in the literature. The focus of the majority of the articles was on the safety and efficacy of loteprednol etabonate 0.5% in post-operative control of inflammation and pain following cataract surgery. There were only three articles with a remote association between loteprednol etabonate and keratoplasty.
Conclusion: Lotemax® ointment may also have potential as a first-line anti-inflammatory agent of choice in postoperative settings of strabismus and penetrating glaucoma, and following low-risk penetrating keratoplasty procedures.

Keywords: loteprednol, inflammation, pain, keratoplasty, surgery, eye

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