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Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections

Authors Goodman, Martin S

Received 25 January 2012

Accepted for publication 20 February 2012

Published 26 March 2012 Volume 2012:8 Pages 149—156

DOI https://doi.org/10.2147/TCRM.S17413

Review by Single-blind

Peer reviewer comments 3

Julian J Goodman, Stanley I Martin

Division of Infectious Diseases, The Ohio State University, Columbus, OH, USA

Abstract: Ceftaroline is a novel broad-spectrum cephalosporin ß-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as multidrug-resistant Streptococcus pneumoniae among other routine Gram positive and Gram negative organisms. It has been approved by the US Food and Drug Administration for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections (ABSSSIs). Ceftaroline is approved for treatment of ABSSSI due to MRSA, however currently there are no data for pneumonia due to MRSA in humans. Herein we review the major clinical trials as well as ceftaroline microbiology, pharmacokinetics, and safety, followed by a look at further directions for investigation of this new agent.

Keywords: ceftaroline, pneumonia, skin infection

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