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Could Inflammaging and Its Sequelae Be Prevented or Mitigated?

Authors Man MQ, Elias PM

Received 22 October 2019

Accepted for publication 17 December 2019

Published 30 December 2019 Volume 2019:14 Pages 2301—2304

DOI https://doi.org/10.2147/CIA.S235595

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Mao-Qiang Man,1,2 Peter M Elias2

1Dermatology Hospital of Southern Medical University, Guangzhou 510091, People’s Republic of China; 2Dermatology Services, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA

Correspondence: Mao-Qiang Man
Dermatology Service (190), 4150 Clement Street, San Francisco, CA 94121, USA
Tel +1 415 575-0539
Fax +1 415 750-2106
Email mqman@hotmail.com

Abstract: Aged humans display a chronic and low-grade inflammation, termed “inflammaging”, which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, Alzheimer’s disease and obesity. Though the origin of aging-associated systemic inflammation is uncertain, epidemiological studies show that inflammatory dermatoses (psoriasis and eczema) are risk factors for some aging-associated systemic disorders, such as type 2 diabetes and atherosclerotic cardiovascular disease. Moreover, recent studies demonstrate that epidermal dysfunction in aged skin not only causes cutaneous inflammation, but also a subsequent increase in circulating levels of proinflammatory cytokines, suggesting that the skin could be a major contributor to inflammaging. This hypothesis is further supported by reductions in circulating levels of proinflammatory cytokines in both aged humans and murine, following improvements in epidermal function with topical emollients. Therefore, correction of epidermal dysfunction could be a novel approach for the prevention and mitigation of certain inflammation-associated chronic disorders in aged humans.

Keywords: aging, inflammation, inflammaging, epidermis, systemic disorders

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