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Could epigenetics help explain racial disparities in chronic pain?

Authors Aroke EN, Joseph PV, Roy A, Overstreet DS, Tollefsbol TO, Vance DE, Goodin BR

Received 23 October 2018

Accepted for publication 4 January 2019

Published 18 February 2019 Volume 2019:12 Pages 701—710

DOI https://doi.org/10.2147/JPR.S191848

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Katherine Hanlon


Edwin N Aroke,1 Paule V Joseph,2 Abhrarup Roy,2 Demario S Overstreet,3 Trygve O Tollefsbol,4 David E Vance,1 Burel R Goodin3

1School of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA; 2Sensory Science and Metabolism Unit (SenSMet), Division of Intramural Research, National Institute of Nursing Research, National Institute of Health, DHHS, Bethesda, MD, USA; 3Department of Psychology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL, USA; 4Department of Biology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL, USA

Abstract: African Americans disproportionately suffer more severe and debilitating morbidity from chronic pain than do non-Hispanic Whites. These differences may arise from differential exposure to psychosocial and environmental factors such as adverse childhood experiences, racial discrimination, low socioeconomic status, and depression, all of which have been associated with chronic stress and chronic pain. Race, as a social construct, makes it such that African Americans are more likely to experience different early life conditions, which may induce epigenetic changes that sustain racial differences in chronic pain. Epigenetics is one mechanism by which environmental factors such as childhood stress, racial discrimination, economic hardship, and depression can affect gene expression without altering the underlying genetic sequence. This article provides a narrative review of the literature on epigenetics as a mechanism by which differential environmental exposure could explain racial differences in chronic pain. Most studies of epigenetic changes in chronic pain examine DNA methylation. DNA methylation is altered in the glucocorticoid (stress response) receptor gene, NR3C1, which has been associated with depression, childhood stress, low socioeconomic status, and chronic pain. Similarly, DNA methylation patterns of immune cytokine genes have been associated with chronic stress states. Thus, DNA methylation changes may play an essential role in the epigenetic modulation of chronic pain in different races with a higher incidence of epigenetic alterations contributing to more severe and disabling chronic pain in African Americans.

Keywords: chronic pain, epigenetics, racial health disparities, epigenomics, DNA methylation, stress
 

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